People often want a product shortcut, but rodent contamination risk is better reduced by removing the source, cleaning correctly, and keeping rodents out than by hoping a room purifier fixes the problem.
A HEPA purifier can be part of a broader cleanup plan, but it should not be treated as the main answer to an active contamination problem.
Respiratory protection, gloves, disinfectants, disposal materials, and rodent-control tools usually matter more than general consumer air gear alone.